Endoplasmic Reticulum

ID #1984

In proteins that span the membranes several times, are they bound by an SRP each time? Or are SRP's only required to get them to the RER?


The Signal Recognition particle binds to the signal sequence which is transcribed by a ribosome. The SRP then pauses translation while it transports the ribosome to the Rough endoplasmic reticulum. Upon association with the RER, the SRP goes back into the cytosol. So to answer your questions, yes and yes. All proteins that span the membrane must be bound by an SRP in order to get to the RER, but so do all the soluble proteins that are involved in the secretory pathway as well.

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