Endoplasmic Reticulum

ID #1978

If in translation ribosomes access more mRNA transcript by physically moving during translocation. How do they do this and proceed with translation when they are stuck to the ER?

It's actually not important whether it's the ribosome doing the moving, the mRNA doing the moving, or both. The important concept is that relative movement is carried out--in other words, the ribosome gets 3 bases closer to the 3' end of the mRNA. If a ribosome is attached to a translocon, clearly it cannot be doing the moving, but it will be able to thread the mRNA through it like ticker tape through an old-fashioned stock ticker.

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