Endoplasmic Reticulum

ID #1862

I had a question about the Glycolipid anchors. In the lecture, this process was said to have no "additional signal sequence" what does that mean exactly in terms of what kind of signal sequence this process starts with; internal or amino terminus signal sequence


If the N terminus of the protein is in the lumen of the ER (and it is in this case), then the protein had an amino terminal signal peptide which was removed. The fact that it was "caught by the tail" near the C terminus means it had a stop transfer sequence, but the C terminal end of the protein is in the cytoplasm, so there were no additional signals.

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