Endoplasmic Reticulum

ID #1855

Do nuclear proteins have to go through the ER to be processed, or do they go directly to the nucleus from the cytoplasm after translation?


If you present an NLS, you get sent to the nucleus. If you present a signal peptide, you get sent to the ER. So those are very separate signals. Plus, in our discussion of the secretory pathway, which begins at the ER, there hasn't been (and won't be) a mechanism to get a protein out of the secretory pathway and into the nucleus. So the answer to your question is "no, they go directly to the nucleus and not through the ER."

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