Endoplasmic Reticulum

ID #1285

For a transmembrane protein, after a stop-transfer sequence is encountered and the protein is ejected into the membrane, what causes the translocon to open back up? The ribosome? You probably mentioned this answer in class, but I didn't write it down.


There isn't automatically a reason why it would need to open back up. In fact, the only thing that will cause it to reopen is an appopriate signal in the form of an internal signal sequence. If there isn't one, the rest of the protein just gets translated out in the cytoplasm.

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