Endoplasmic Reticulum

ID #1278

If a translocon is presented with a stop-transfer sequence, does the protein get cleaved off/into the ER membrane right at that moment, exposing the C-terminus to the cytosol? Does having an internal signal sequence and NOT one at the N-terminus ALWAYS mean the N-terminus will end up in the cytosol?


No, stop transfer sequences do not get cleaved; they always remain part of the protein and act as a membrane spanning region. And yes, for purposes of MCB 150, an internal signal peptide means your N-terminus will end up in the cytosol.

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