Endoplasmic Reticulum

ID #1275

What energy is required to attach the SRP to the signal sequence for a protein destined for the ER? Also, is any energy required to release that protein from the signal sequence?

This won't be on your exam on Thursday, but the translocation of protein into the ER appears to be a GTP-dependent process, since both SRP and SRP receptors are seen to have GTP binding sites. I don't believe that the binding of SRP to the signal peptide requires any energy, but removing it does.

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