Endoplasmic Reticulum

ID #2453

When does the translocon open? Is it when the SRP binds to the receptor, or when the ribosome is situated properly? Or is it all of the above?

Once the Signal Recognition Particle has brought the polypeptide and the ribosome to the ER, it docks with the SRP receptor protein. That binding positions the ribosome properly over the translocon at the same time. After docking SRP releases the its cargo at the same time the translocon opens. At that point translation resumes. 

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