Endoplasmic Reticulum

ID #2452

When a protein gets cut from its stop transfer sequence that is in the translocon and gets added to the GPI anchor, doesn't that affect the protein because some of its amino acids are missing? I'm not sure how the protein gets cut while still keeping all of its amino acids, or is this saying the the amino acids that are part of the stop transfer sequence are not important?


The region of the protein that gets omitted by GPI anchoring was not important to the function of the protein. So you are correct that amino acids are not retained, but that was part of the plan all along. 

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