Endoplasmic Reticulum

ID #2448

So if the ribosome stays attached to the translocon even after a stop transfer sequence, how does the ribosome disconnect when translation is finished?


The stop transfer sequence is a signal to the translocon, not to the ribosome. 
The ribosome simply continues translating the mRNA until it encounters a stop codon. Once the ribosome reaches a stop codon, a release factor enters the A site and then causes the entire ribosome-mRNA-tRNA-polypeptide complex to dissociate into mRNA, tRNA, finished protein, and the 2 subunits of the ribosome. This occurs whether the ribosome is membrane bound or cytosolic. 

Print this record Print this record
Send to a friend Send to a friend
Show this as PDF file Show this as PDF file
Export as XML-File Export as XML-File