Endoplasmic Reticulum

ID #2365

Does it take energy when the chaperone BiP bind to an UNFOLDED protein (as protein is translated and inserted into lumen of rough ER)?


No, it does not take energy for BiP to bind an unfolded protein. I believe that it does, however, require ATP to rachet (pull) the protein into the lumen of the ER, thus driving posttranslational translocation. (This is similar to what occurs with Hsp70 in the matrix of the mitochondria). ATP will also be required to remove BiP from the protein once it is folded correctly. 

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