Endoplasmic Reticulum

ID #2272

Can you clarify the difference between stop transfer and internal sequences with respect to their distance from the amino terminus? Also how does that affect whether the signal sequence is chopped off before/after/during the reading and transfer of these other sequences?

The stop transfer sequence(s) and the internal signal sequence(s) can be varied distances away from the amino terminus. Distance from the N-terminus doesn't control whether or not the signal is chopped off. 
Only the amino (N)-terminal signal sequence is cleaved off by the signal peptidase. The internal and stop transfer signal sequences are never cleaved. 

You'll want to look over Lecture 27 a little more because it sounds like you're confused on the details of amino, internal, and stop transfer sequences that were discussed in lecture.

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