ID #1996

I'm somewhat confused about the process in which the few mitochondrial proteins encoded in the nucelus come in to the mitochondria. I get that the chaperonins keep the proteins from folding until they reach the "tim" and "tom," but what happens afterwards?

It isn't a "few" mitochondrial proteins encoded in the nuclear genome, it's 95% of all mitochondrial proteins coded for in the nuclear genome. For soluble proteins working in the matrix, once they get transported through Tom and Tim, they are assisted in folding and perform whatever functions they were designed to carry out, like pyruvate oxidation, Krebs cycle, electron transport, oxidative phosphorylation, mitochondrial protein synthesis (of the other 5%), etc.

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