ID #1852

From my understanding, and lecture notes, the matrix is negatively charged. The N-terminal signal sequence is positively charged. So it makes sense that this electrochemical gradient would facilitate the movement of positive charges to the negatively charged matrix. However, the N-terminal amino sequence is cleaved after the protein passes through TOM/TIM, so wouldn't this make the protein negative and thus deter the protein from being threaded through?

It's not that the matrix is negative, it's that it's less positive. So there won't be a repulsion, and once the presequence has been removed, the momentum of the movement of the protein is sufficient to get it far enough into the matrix for the next set of chaperone proteins to grab and "tug" gently at it.

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