ID #1231

Is it true that once a mitochondrial protein is inside the matrix you don't need Hsp70 because the protein is already unfolded?

No, the Hsp70s from the cytoplasm stay in the cytoplasm, so you need to bind a whole new set of Hsp70s--different ones--in the matrix to keep the protein unfolded until it can get to the chaperonin complex.

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