Mitochondria

ID #1216

This is probably self-evident, but I was just confused about the membrane proteins of the mitochondria. Are they not involved with the ER at all? I mean do they have their own stop transfer sequences that TOM and TIM recognize, separate from ribosomal translation on the RER?


Yes, your observation is very good. Mitochondrial proteins never go through the ER, but some mitochondrial proteins are membrane-bound, aren't they? That means they have to have additional targeting signals, analagous to (but NOT identical to) stop transfer sequences and internal signal peptides that get them inserted in mitochondrial membranes.

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