Nucleo-Cytoplasmic Exchange

ID #1215

With regard to importin and exportin, I know that GTP hydrolysis is used to recycle the carrier proteins, but why does GTP hydrolysis occur in the cytoplasm?


The answer to this question goes beyond what we discussed in class, but it lies in the additional molecules that are part of this process. There is a gradient of one of these other molecules, called Ran, where more of it is in the cytoplasm. Ran is what hydrolyzes the GTP, so that's at the heart of why the GTP is hydrolyzed in the cytoplasm.

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