Nucleo-Cytoplasmic Exchange

ID #2435

It says in my notes that the process of importin binding to a cargo protein and bringing it into the nucleus is energy-dependent in order to "charge" it. Is this referring to the attachment of NLS to the cargo protein? I know that when exportin is involved, it's an energy-dependent process in order to recycle the exportin. Is it the same case for importin? or does "charging" have something to do with it?

Like exportin, the energy dependence of importins is to recycle them into a form that can bind to another NLS-bearing protein and bring that cargo into the nucleus. For both importin and exportin, this energy-dependent recycling requires GTP and occurs in the cytoplasm. 
The binding of the importin to the cargo is not directly energy dependent. 

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