Nucleo-Cytoplasmic Exchange

ID #2261

What is the purpose of FG-proteins? I know it is lined in the central channel...

The importin-NLS-containing cargo complex has to get through the nuclear pore complex. But how? It binds to proteins in the cytoplasmic filaments of the nuclear pore complex first. Then, it binds to specific nuclear pore proteins located further and further in the channel. One type of nuclear pore proteins it is binding in the central region of the channel are the FG-proteins. These proteins are named FG because they contain multiple repeats of the amino acids phenylalanine (Phe or F) and glycine (Gly or G). So the purpose of FG-proteins is to exist in the central channel region of the nuclear pore complex and bind importin-NLS containing cargo complexes at one stage of their travel through the pore. 

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