Nucleo-Cytoplasmic Exchange

ID #2258

What is the nuclear basket for? What is the role of the cytoplasmic filament and ring? What is the spoke-ring assembly for?


The nuclear pore complex (NPC) expands from the inside of the nucleus to the cytoplasmic side of the nuclear membrane. The nuclear basket is on the nuclear side and the filaments are on the cytoplasmic side. The nucleoporins that form the NPC are arranged in an eight-fold symmetrical manner that gives the spoked appearance. 
The basket is the location where the NES is recognized and the filaments are the location where the NLS is recognized. The exact mechanism of these two regions is unknown, but it is believed that the cytoplasmic filaments can wave the importin and its cargo toward the the pore. The spoked pattern is a result of the symmetry that allows for the formation of a channel. 

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