Nucleo-Cytoplasmic Exchange

ID #2005

When it says Protein X is normally localized to the cytoplasm, does "localized" mean it is made and stays in the cytoplasm or that it was made in the cytoplasm but then localized to the nucleus and then localized to the cytoplasm meaning it has an NES?

The word localized gives no indication where it was made. It simply indicates where it is. As far as making sense, I can make two comments. First, this is an artificial scenario, so it doesn't have to conform to the way it might actually work in a real cell. But more importantly, second, consider one of those shuttle proteins that binds to a mRNA molecule. They are made in the cytoplasm, get localized to the nucleus, then get localized to the cytoplasm, then back to the nucleus, and so forth. I'm not saying that's what's happening here, but it's an example that similar examples do in fact occur in the cell.

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