Nucleo-Cytoplasmic Exchange

ID #2004

Are localization signals necessary to move a protein through the normal course of action, from the ER to the Golgi to the vesicles, or do you only need them to get to specialized places like lysosomes, the nucleus, mitochondria, etc.?

It was initially thought, and still possible, that once you get to the ER, the default behavior is to continue on through the secretory pathway. But researchers continue to find new patches of amino acids that target proteins to one location or another, and this has changed a lot in just the last couple years. So it's also possible that proteins need to explicitly display an appropriate signal in order to get anywhere (other than the cytoplasm, I guess), and we just haven't found all the signals yet.

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