Nucleo-Cytoplasmic Exchange

ID #2003

How come a sigma factor doesn't have an NLS? Also, do Aminoacyl tRNA synthetases have an NES or neither?


Sigma factors are found in bacterial RNA polymerases, which means there's no nucleus to be imported into.

 

When an aminoacyl tRNA synthetase is made, it's translated out in the cytoplasm. Since that's also where it's supposed to do its job, there's no need to move it to a different cellular location. And since the default behavior is to stay where you are unless you present a signal specifying otherwise, there would be no need for an NLS or an NES on an aminoacyl tRNA synthetase.

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