ID #1827

Does 'degeneracy' with regards to the third base in a codon lead to missense mutation? What exactly does null phenotype mean, and is that important to know besides that it is the effect of nonsense mutations?

If you change the third base and serve as an example of degeneracy, you wouldn't be a missense mutation, you'd be a same sense mutation. But beyond that, there's no process -- a change has been made in the DNA which leads to a change in the mRNA, which may or may not lead to a change in the protein.

The word phenotype indicates an observable trait. You have genes in your genome for eye color; that's your genotype. You have brown eyes; that's your phenotype. A null phenotype would indicate that you aren't making a functional protein at all, so there would be no phenotype for that protein's role.

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