Mutations

ID #1252

In my lecture notes, it states that, "New DNA gets methylated at adenine residues within the sequence 5’–GATC–3'." What do you mean by new DNA? The new DNA doesn't mean the daughter strands, right? I thought that the parent strands were methylated so that enzymes could distinguish them from daughter strands.


No, I mean that the new, unmethylated DNA will soon get methylated so that both strands are methylated. This way in the next round of replication, both can be used and identified as parent. This gives you a rather brief window of opportunity for the mismatch repair system to function.

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