Mutations

ID #1251

I have a quick question about Mismatch Repair... Why do the enzymes used during repair cut out so much of the nonmethylated strand of DNA? Why don't they just remove the incorrect base pair(s) and replace those?


It may seem like a lot more work, but let's say that looped out region is 1000 bases in length. DNA polymerase III, which fills that region back in, can move at about 1000 bases per second, so it's really not a big deal to replace that long a stretch. And in the end, it turns out to be easier to do it this way than to try to be so specific about where to cut and pick out only one base.

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