Mutations

ID #1250

For mismatch repair system, I am very confused with that whole process--In particular, the methylation process. Is it that when DNA is being synthesized, the adenine residues are methylated with 5-GATC-3?


Methylation isn't going to occur until several minutes (~10?) after DNA replication has occurred. This gives the mismatch repair system (which by the way isn't responsible for the actual methylation step) the time it needs to detect and fix mismatched bases.

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