Mutations

ID #1243

I have a quick question about mismatch repair. I was looking in the book and it says that methyl groups are added to some guanines, but in my lecture notes notes I have written down that the methyl groups are added at adenines. I know you normally say to follow what you say in lecture, but I was just curious to where the methyl groups are added to.


Every semester that we've used the Purves text, a student reading carefully poses this question. Congratulations! Frankly, I don't know why the textbook makes this statement. There are a variety of reasons why an organism would methylate its DNA, and methylation-directed mismatch repair (MMR) is only one of these reasons. But for the organism we're studying as our representative example of this process, E. coli, that methylation occurs on adenines within GATC sequences.

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