Mutations

ID #2429

So do we have to know both the fact that for bacteria, methyl group adds to only A and for humans, methyl group adds to both G and C?


Yes, you should be comfortable with how DNA methylation occurs in bacteria. In humans, methyl groups are added to cytosine residues of a cytosine-guanine dinucleotide (this is shown as CpG, which means C-phosphate-G, as in the C is separated from the G by a phosphodiester linkage). Only the cytosine is methylated, not the guanine. Not every cytosine in a CpG dinucleotide is methylated. Exactly how methylation affects mismatch repair was discussed in lecture for E. coli, so you should be most familiar with how it works in bacteria. 

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