Mutations

ID #2257

Why is this statement false: "Deletions that occur in the coding region of a gene typically result in a protein product with slightly reduced function?"


If you make a deletion, you're not doing a simple single nucleotide base substitution. You're ripping out part of the gene. That might not have an effect if the part of the gene you delete is an intron, because those would be deleted anyway. But this statement is telling you the part of the gene that you're deleting is in an exon (aka the coding region). So, deleting part of the coding region would be really really bad. If you were able to still make a protein, it wouldn't be like the protein was supposed to be because it's missing a larger region of DNA due to the deletion. So, you typically won't result in a protein product with SLIGHTLY reduced function.

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