The Nucleus and its Functional Domains

ID #1821

I was just wondering if the point of showing all the slides about FISH and chromosome painting was to demonstrate that the chromosomes are separated into domains? Also I was just wondering what exactly chromosome painting was used for, for these slides?


Yes, there was a long build-up for that one payoff slide showing how we know that even during interphase, chromosomes occupy their own territory and don't encroach on the other territories.

Chromosome painting was used to "light up" entire chromosomes, so when we do that last experiment, we see the entire territory occupied by a given chromosome. If you attempted that last experiment just using FISH, you'd only see little spots of color in the interphase nucleus, and it wouldn't really prove anything.

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