The Nucleus and its Functional Domains

ID #1817

How the tandem arrays and how 5.8S, 18S, 28S fit together ? Also how are the 5 different chromosomes incorporated with the arrays and the S's ?

The 5.8S, 18S, and 28S rRNAs are transcribed as part of a larger, single rRNA molecule that we call the 45S pre-rRNA. There are several hundred copies of this 45S rRNA gene in the human genome, all arranged in clusters of back-to-back copies called tandem repeats. 5 different human chromosomes have these tandem repeats in them, and those regions of DNA are collected together to form the nucleolus.

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