The Nucleus and its Functional Domains

ID #1202

Can you explain what exactly tandem arrays are? Are they just sections of the nucleolus that house the 5.8S, 18S, and 28S rRNA segments? Is it in these tandem arrays that these subunits of rRNA are made?

On some chromosomes, there are multiple copies of the 45S pre-rRNA gene that lie back to back to back... This is called a tandem repeat of the 45S pre-rRNA gene. Each has its own promoter and terminator, but there is very little spacer DNA between the terminator for copy 1 and the promoter for copy 2 and so on. This is ultimately where the 18S, 5.8S, and 28S rRNAs come from, which then get incorporated into ribosomal subunits.

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