The Nucleus and its Functional Domains

ID #2419

I thought centromere was the term used for the point where the two sister chromatids connected, but in interphase there isn't a duplicate so why is there a centromere? Also, in interphase, these chromosomes appear to be all mixed together, so how is it that they are separate?

The centromeric region is the site of attachment of sister chromatids. However, there is a specific DNA sequence in this region that is recognized and bound by the proteins involved in separating sister chromatids, so even in interphase the DNA component of the centromere is present. In two-dimensional figures, the chromosomes appear to be mixed together, but remember that a nucleus is a 3-dimensional space. In 3-dimensional space chromosomes occupy their own territories, and even the chromosome arms don't overlap. 

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