The Nucleus and its Functional Domains

ID #2357

Since the nuclear "speckles are storage sites of splicing components, which are then recruited to actively transcribed genes where pre-mRNA processing occurs.", is it safe to say that you would expect to see nuclear speckles in inter chromosomal domains?


Yes, speckles (clusters of splicing factors) reside in interchromosomal domains. Actively transcribed DNA is looped into interchromosomal domains where the speckles are located.

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