The Nucleus and its Functional Domains

ID #2356

Can someone explain what Mr. Mehrtens was saying about replicons, ori, and foci. I need help sorting out which ones give way to which ones.

A replicon is the amount of DNA replicated from a single ori. Since bacteria only have one ori, they only have one replicon. The human genome has approximately 30,000 ori, so there will also be 30,000 replicons. A focus of replication is a grouping of oris that are brought to the replication machinery. Each focus of replication contains approximately 200-300 ori, so 200-300 replicons. I mentioned that the human genome has about 30,000 oris, so one would predict that there would be about 100 foci of replication. 

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