ID #2128

In the first experiment where the triplet code was identified, the researchers synthesized an RNA molecule that was: 5'-AAAAAAAAAAAAAAAAAAAAAAAAAAA-3' and they came up with just all lysines, but how is this possible if there's no start codon present to begin translation?

This is a good example of what happens in vivo (in a cell) and what is possible in vitro (in a test tube). These artificial translation machines can begin incorporating amino acids at any point without the need for an initiator codon. Clearly, this is not possible in a living cell, but it's helpful to be able to try things in a lab that don't normally happen in a cell.

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