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ID #2032

Could you please explain why GTP is hydrolyzed, rather than ATP, during the elongation phase? Also, during lecture you mentioned that energy comes "directly and indirectly" when you form a polypeptide. Could you please elaborate upon this as well?


It's really just a matter of what fits into the enzyme's active site. Adenine might look like guanine, but they're not exactly the same, and enzymes will usually "prefer" one or the other but not both.

 

As far as the direct/indirect thing, the energy for peptide bond formation comes directly from the breaking of the bond between the amino acid and the tRNA, but it comes indirectly from the ATP used to charge that tRNA.

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