Transcription and RNA Processing

ID #1741

If the very first nucleotide in a nucleic acid strand remains a nucleoside triphosphate, how is the triphosphate bridge connecting the 5' end of the 7-methylguanosine to the 5' end of the mRNA created during RNA processing in eukaryotes (in other words, where does the energy for the creation of the covalent bond come from)?

In that primary mRNA, there is in fact a triphosphate group at the 5' end. But the incoming modified dGTP will also have a triphosphate. In a short series of reactions, three of those six phosphate groups are removed as an energy source to link the cap to the mRNA.

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