Transcription and RNA Processing

ID #1166

What does a footprint region mean?

In general terms, a molecular footprint is the number of bases (or base pairs) that are physically covered by a protein whose job it is to bind to that nucleic acid. When a ribosome "sits" on a mRNA, it has a width approximately equal to the length of 80 bases, so it is said to have an 80 base footprint.  RNA polymerases also have a footprint, which varies from one polymerase to the next, and even varies based on which step in transcription you're looking at.

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