MCB 150
The Molecular and Cellular Basis of Life
School of Molecular and Cellular Biology
University of Illinois at Urbana-Champaign
murray@illinois.edu | mehrtens@illinois.edu
course home pagecourse contactUniversity of Illinois

 
Course Syllabus

Day

Lecture Topic

Reading Assignment

Discussion

 Monday, August 27

Course Introduction

Freeman
Chapters 1 & 2

Discussion 1: Introduction/ Scientific Reasoning Inventory

 Wednesday, August 29

Domains of Life; Cells and Molecules I

Freeman:
Section 1.5
Section 7.1
Section 20.4, subheading "The Natural History of Prokaryotic Genomes"
Section 26.1
Becker:
Section 4.2 through page 79

Friday, August 31

Cells and Molecules II; Carbohydrates I

Freeman:
Section 7.2
Section 3.1, Header: How Do Amino Acids Link to Form Proteins? (pp. 81-82)
Chapter 5 (will continue into next class period)
Becker:
Section 4.3 on: Plasma Membrane, Nucleus, Mitochondria, ER, Golgi, Ribosomes
Section 3.3 (will continue into next class period)

 Wednesday, September 5

Carbohydrates II

Freeman:
Chapter 5 (continued from previous class period)
Becker:
Section 3.3 (continued from previous class period)

No Discussions this week!
Labor Day – Monday, September 3

 Friday, September 7

Proteins I - Amino Acids and Levels of Protein Organization

Freeman:
Section 3.1
Section 3.2
Becker:
Section 3.1

 Monday, September 10
(Add Courses, Section Change Deadline 5:00 PM)

Denaturation of Proteins; Enzymes and Enzyme Inhibition

Freeman:
Chapter 3, Section 3.3; Chapter 8, Sections 8.1, 8.3, 8.4
Becker:
Chapter 6, Sections 6.1, 6.2 (these pages are helpful but optional)

Discussion 2:
Macromolecules

 Wednesday, September 12

Enzyme Inhibition continued; Nucleic Acids

Freeman:
Chapter 4, Section 4.1; Chapter 6, Section 6.1
Becker:
Chapter 3, Section 3.2

 Friday, September 14

Lipids & Biomembranes

Freeman:

  • Chapter 6, Sections 6.2, 6.3, and 6.4

 Monday, September 17

Biomembranes II & Metabolism I

Becker:
Chapter 7 (this chapter is informative but goes above our level, and is therefore optional)

Discussion 3:
Exam 1 Preparation

Wednesday, September 19

Optional  In-Class Review

Thursday, September 20

Exam I (7-9 PM)

Friday, September 21

Metabolism II – Glycolysis and Krebs Cycle

Freeman:
Chapter 9, Sections 9.1 through 9.4

Monday, September 24

Metabolism III – ETC, Fermentation and Summary

Freeman:
Chapter 9, Sections 9.5 and 9.6

Discussion 4: Metabolism

Wednesday, September 26

DNA Structure and Organization I

Freeman:
Chapter 4, Section 4.2; Chapter 15, Section 15.1
Becker:
Chapter 3, Section 3.2

Friday, September 28

DNA Structure and Organization II

Freeman:
Chapter 19, Page 381
Becker:
Chapter 16, Section 16.1. 16.2, 16.3 through page 448

Monday, October 1

DNA Replication I

Freeman:
Chapter 15, Sections 15.2–15.4
Becker:
Chapter 14, Section 14.1, Pages 481–end of section (just the section on Telomeres)

Discussion 5:
The History of the Double-Helix Discovery

Wednesday, October 3

DNA Replication II

Freeman:
Chapter 15, Sections 15.3 and 15.4

Friday, October 5

Transcription in Bacteria

Freeman:
Chapter 17, Section 17.1
Becker:
Chapter 18, Section 18.2 (just the sub-sections on Bacterial Transcription)

Monday, October 8

Transcription in Eukaryotes; RNA Processing I

Freeman:
Chapter 17, Section 17.2
Becker:
Chapter 18, Section 18.2 (just the sub-sections on Eukaryotic Transcription, p. 516–520)

Discussion 6:
DNA Transcription/
Translation Models

 

Wednesday, October 10

RNA Processing II; The Genetic Code

Freeman:
Chapter 16, Section 16.3
Becker:
Chapter 18, Section 18.3 from page 525 to page 530

Friday, October 12

Translation I

Freeman:
Chapter 17, Sections 17.3–17.5 (we will only get to Initiation in 17.5 on Friday)

Monday, October 15

Translation II

Freeman:
Chapter 17, Section 17.5

Discussion 7:
Exam 2 Preparation

Wednesday, October 17

Optional In-Class Review

Thursday, October 18

Exam II (7-9 PM)

Friday, October 19
(Course Drop Deadline 5 PM)

Nuclear Structure & Domains

Freeman:
Chapter 12, Section 12.1
Becker:
Chapter 16, Section 16.3 Key Technique, pp. 444–445
Chapter 16, Section 16.4 from the header The Nucleusup to (but not including) the section titled Molecules Enter and Exit the Nucleus Through Nuclear Pores
Chapter 16, Section 16.4 from the header The Nucleus is Mechanically Integrated with the Rest of the Cellto the end of the chapter

Monday, October 22

The Nucleolus, Mutations I

Freeman:
Chapter 15, Section 15.5
Becker:
Monday's readings are a continuation of Friday's readings

Discussion 8: Direct-to-Consumer Genetic Testing

 

Wednesday, October 24

Mutations II

Freeman:
Chapter 15, Section 15.5; Chapter 16, Section 16.4
Becker:
Chapter 17, pages 488 & 489

Friday, October 26

Mutations III

Freeman:
Chapter 15, Section 15.5;
Chapter 16, Section 16.4

March 19 – 23

No Classes – Spring Vacation

Monday, October 29

Nucleo-Cytoplasmic Transport, Mitochondrial Genomes and Protein Transport

Freeman:
Chapter 7, Section 7.4
Becker:
Chapter 16, pp. 453–459

Discussion 9: Jeopardy

Wednesday, October 31

The Secretory Pathway;
The Endoplasmic Reticulum I

Freeman:
Chapter 7, Section 7.5, up to (but not including) the header "Moving from the ER to the Golgi"
Becker:
Chapter 12, pp. 314–316
Chapter 19, pp. 556-561, beginning with the header "Protein Targeting and Sorting" and ending with (but not including) the subheader that begins "Protein Folding and Quality Control..."
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms, and ignore the part about nuclear ribosomes. (It's not incorrect, just beyond the scope of this course)

Friday, November 2

The Endoplasmic Reticulum II

Becker:
Chapter 12, Section 12.1
Chapter 12, Section 12.3 (from beginning of section up to but not including Further Glycosylation Occurs in the Golgi on p. 322).
Chapter 19, Section 19.5, pp. 561-562 (from the header Protein Folding and Quality Control up to (but not including) the header Posttranslational Import

Monday, November 5

The Golgi Apparatus

Freeman:
Chapter 7, Section 7.5, from Moving from the ER to the Golgi up to (but not including) Recycling Material in the Lysosome
Becker:
Chapter 12, pp. 319–324, sections involving the Golgi
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

Discussion 10: Mitochondrial Genomes & Transport and Signaling

Wednesday, November 7

Lysosome & Endosomes

Freeman:
Chapter 7, p. 150, short sub-header titled Lysosomes; Section 7.5, from Recycling Material in the Lysosome to end of section

Friday, November 9

Cytoskeleton I - Actin Filaments

Freeman:
Chapter 7, Section 7.6, up to section titled Microtubules
Becker:
Chapter 13, Section 13.1
Chapter 13, Section 13.3 through the bottom of p. 368
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

Monday, November 12

Cytoskeleton II – Actin & Myosin

Freeman:
Chapter 7, Section 7.6, up to section titled Microtubules
Becker:
Chapter 14, Section 14.3
Chapter 14, Section 14.4 (from beginning of section up to but not including The Regulation of Muscle Contraction...on p. 394).
Chapter 14, Section 14.5

Discussion 11: Exam 3 Preparation

Wednesday, November 14

Optional Review

Thursday, November 15

Exam III (7-9 PM)

Friday, November 16

Cytoskeleton III - Microtubules

Freeman:
Chapter 7, Section 7.6, pp. 164-165, from section titled Microtubules up to subheader titled Motor Proteins Pull...
Becker:
Chapter 13, Section 13.2 through p. 361
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

November 18 – November 26

Thanksgiving Vacation

Monday, November 26

Cytoskeleton IV – Centrosomes, Centrioles & Cilia

Freeman:
Chapter 7, Section 7.6, pp. 165-168, from section titled Motor Proteins Pull... to the end of the chapter
Becker:
Chapter 14, Section 14.1
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

Discussion 12: Vaccinations

 

Wednesday, November 28

Cell Cycle Introduction

Freeman:
Chapter 12, Sections 12.1 & 12.2
Becker:
Chapter 24, Section 24.1 & 24.2
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

Friday, November 30

The Events of M-Phase

Freeman:
Chapter 12, Sections 12.1 & 12.2
Becker:
Chapter 24, Section 24.1 & 24.2
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

Monday, December 3

Genetic Regulation in Bacteria I

Freeman:
Chapter 18, Sections 18.1 – 18.3
We will be working through an animated tutorial posted in Compass and you are encouraged to go through it before class

Discussion 13: Exam 4 (Final Exam) Preparation

 

Wednesday, December 5

Genetic Regulation in Bacteria  II,
Viruses I

Freeman:
Chapter 18, Sections 18.1 – 18.3 (Continued from Monday)
Chapter 33, pp. 682–687, up to section header "Analyzing the Phases of Replicative Growth"

Friday, December 7

Viruses II

Freeman:
Chapter 33, pp. 687-693, up to section 33.3

Monday, December 10

Recombinant DNA & Genetic Engineering I

Freeman:
Chapter 20, Section 20.1

No Discussions this week!

 

Wednesday, December 12

Recombinant DNA & Genetic Engineering II

Freeman:
Chapter 20, Section 20.

Thursday, December 13

Reading Day: No Classes

Friday, December 14

Final Exam 7:00 – 10:00 PM