MCB 150
The Molecular and Cellular Basis of Life
School of Molecular and Cellular Biology
University of Illinois at Urbana-Champaign
murray@illinois.edu | mehrtens@illinois.edu
course home pagecourse contactUniversity of Illinois

 
Course Syllabus

  Orange dates indicate tentative traditional class periods
  Blue dates indicate tentative flipped class periods

Day

Lecture Topic

Reading Assignment

Discussion

 

Wednesday, January 17

 

Course Introduction

Freeman

Chapters 1 & 2

No Discussions this week!

 

 

 

 

 

Friday, January 19

Domains of Life; Cells and Molecules I

Freeman:

Section 1.5

Section 7.1

Section 20.4, subheading "The Natural History of Prokaryotic Genomes"

Section 26.1

Becker:

Section 4.2 through page 79

 

 

 

 

 

 

 

 

Monday, January 22

Cells and Molecules II; Carbohydrates I

Freeman:

Section 7.2

Section 3.1, Header: How Do Amino Acids Link to Form Proteins? (pp. 81-82)

Chapter 5 (will continue into next class period)

Becker:

Section 4.3 on: Plasma Membrane, Nucleus, Mitochondria, ER, Golgi, Ribosomes

Section 3.3 (will continue into next class period)

 

 

Wednesday, January 24

Carbohydrates II

 

Freeman:

Chapter 5 (continued from previous class period)

Becker:

Section 3.3 (continued from previous class period)

Discussion 1: Introduction/ Scientific Reasoning Inventory

 

 

 

 

Friday, January 26

Proteins I - Amino Acids and Levels of Protein Organization

Freeman:

Section 3.1

Section 3.2

Becker:

Section 3.1

 

Monday, January 29

(Add Courses, Section Change Deadline 5:00 PM)

Denaturation of Proteins; Enzymes and Enzyme Inhibition

 

Freeman:

Chapter 3, Section 3.3; Chapter 8, Sections 8.1, 8.3, 8.4

Becker:

Chapter 6, Sections 6.1, 6.2 (these pages are helpful but optional)

Discussion 2:

Macromolecules

 

Wednesday, January 31

Enzyme Inhibition continued; Nucleic Acids

Freeman:

Chapter 4, Section 4.1; Chapter 6, Section 6.1

Becker:

Chapter 3, Section 3.2

 

Friday, February 2

Lipids & Biomembranes

 

Freeman:

Chapter 6, Sections 6.2, 6.3, and 6.4

 

 

 

Monday, February 5

Biomembranes II & Metabolism I

 

Becker:

Chapter 7 (this chapter is informative but goes above our level, and is therefore optional)

Discussion 3:

Exam 1 Preparation

 

Wednesday, February 7

 

Optional Review

 

 

 

Thursday, February 8

 

Exam I (7-9 PM)

 

 

 

Friday, February 9

 

Metabolism II – Glycolysis and Krebs Cycle

Freeman:

Chapter 9, Sections 9.1 through 9.4

 

 

 

 

Monday, February 12

Metabolism III – ETC, Fermentation and Summary

Freeman:

Chapter 9, Sections 9.5 and 9.6

 

Discussion 4: Metabolism

 

 

Wednesday, February 14

 

DNA Structure and Organization I

Freeman:

Chapter 4, Section 4.2; Chapter 15, Section 15.1

Becker:

Chapter 3, Section 3.2

 

 

 

Friday, February 16

 

DNA Structure and Organization II

Freeman:

Chapter 19, Page 381

Becker:

Chapter 16, Section 16.1. 16.2, 16.3 through page 448

 

 

Monday, February 19

 

DNA Replication I

Freeman:

Chapter 15, Sections 15.2–15.4

Becker:

Chapter 14, Section 14.1, Pages 481–end of section (just the section on Telomeres)

Discussion 5:

The History of the Double-Helix Discovery

 

Wednesday, February 21

DNA Replication II

Freeman:<

Chapter 15, Sections 15.3 and 15.4

 

 

 

Friday, February 23

 

Transcription in Bacteria

Freeman:

Chapter 17, Section 17.1

Becker:

Chapter 18, Section 18.2 (just the sub-sections on Bacterial Transcription)

 

 

 

Monday, February 26

Transcription in Eukaryotes; RNA Processing I

Freeman:

Chapter 17, Section 17.2

Becker:

Chapter 18, Section 18.2 (just the sub-sections on Eukaryotic Transcription, p. 516–520)

Discussion 6:

DNA Transcription/

Translation Models

 

 

 

Wednesday, February 28

RNA Processing II; The Genetic Code

Freeman:

Chapter 16, Section 16.3

Becker:

Chapter 18, Section 18.3 from page 525 to page 530

 

 

Friday, March 2

Translation I

 

 

Freeman:

Chapter 17, Sections 17.3–17.5

 

 

Monday, March 5

Translation II

Freeman:

Chapter 17, Section 17.5

 

Discussion 7:

Exam 2 Preparation

 

Wednesday, March 7

 

Optional Review

 

 

Thursday, March 8

 

Exam II (7-9 PM)

 

 

Friday, March 9

(Course Drop Deadline 5 PM)

 

Nuclear Structure & Domains

 

Freeman:

Chapter 12, Section 12.1

Becker:

Chapter 16, Section 16.3 Key Technique, pp. 444–445

Chapter 16, Section 16.4 from the header The Nucleusup to (but not including) the section titled Molecules Enter and Exit the Nucleus Through Nuclear PoresChapter 16, Section 16.4 from the header The Nucleus is Mechanically Integrated with the Rest of the Cell to the end of the chapter

 

 

Monday, March 12

 

The Nucleolus, Mutations I

Freeman:

Chapter 15, Section 15.5

Becker:<

Monday's readings are a continuation of Friday's readings

Discussion 8: Direct-to-Consumer Genetic Testing

 

Wednesday, March 14

 

Mutations II

Freeman:

Chapter 15, Section 15.5; Chapter 16, Section 16.4

Becker:

Chapter 17, pages 488 & 489

 

 

 

Friday, March 16

Mutations III

 

Freeman:

Chapter 15, Section 15.5;

Chapter 16, Section 16.4

 

 

March 19 – 23

No Classes – Spring Vacation

 

Monday, March 26

Nucleo-Cytoplasmic Transport, Mitochondrial Genomes and Protein Transport

Freeman:

Chapter 7, Section 7.4

Becker:

Chapter 16, pp. 453–459

 

Discussion 9: Jeopardy

 

 

Wednesday, March 28

The Secretory Pathway;

The Endoplasmic Reticulum I

 

Freeman:

Chapter 7, Section 7.5, up to (but not including) the header "Moving from the ER to the Golgi"

Becker:

Chapter 12, pp. 314–316
Chapter 19, pp. 556-561, beginning with the header "Protein Targeting and Sorting" and ending with (but not including) the subheader that begins "Protein Folding and Quality Control..."
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms, and ignore the part about nuclear ribosomes. (It's not incorrect, just beyond the scope of this course)

 

 

 

 

 

 

 

Friday, March 30

 

The Endoplasmic Reticulum II

Becker:

Chapter 12, Section 12.1

Chapter 12, Section 12.3 (from beginning of section up to but not including Further Glycosylation Occurs in the Golgi on p. 322). Chapter 19, Section 19.5, pp. 561-562 (from the header Protein Folding and Quality Control up to (but not including) the header Posttranslational Import

 

 

 

 

 

 

 

 

Monday, April 2

The Golgi Apparatus

Freeman:

Chapter 7, Section 7.5, from Moving from the ER to the Golgi up to (but not including) Recycling Material in the Lysosome

Becker:

Chapter 12, pp. 319–324, sections involving the Golgi
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

Discussion 10: Mitochondrial Genomes & Transport and Signaling

 

 

 

Wednesday, April 4

 

Lysosome & Endosomes

Freeman:

Chapter 7, p. 150, short sub-header titled Lysosomes; Section 7.5, from Recycling Material in the Lysosome to end of section

 

 

 

 

 

 

Friday, April 6

 

Cytoskeleton I - Actin Filaments

Freeman:

Chapter 7, Section 7.6, up to section titled Microtubules

Becker:

Chapter 13, Section 13.1

Chapter 13, Section 13.3 through the bottom of p. 368
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

 

 

 

 

 

Monday, April 9

 

Cytoskeleton II – Actin & Myosin

Freeman:

Chapter 7, Section 7.6, up to section titled Microtubules

Becker:

Chapter 14, Section 14.3

Chapter 14, Section 14.4 (from beginning of section up to but not including The Regulation of Muscle Contraction...on p. 394).

Chapter 14, Section 14.5

Discussion 11: Exam 3 Preparation

 

Wednesday, April 11

 

 

Optional Review

 

Thursday, April 12

 

 

Exam III (7-9 PM)

 

 

 

 

 

 

Friday, April 13

 

Cytoskeleton III - Microtubules

Freeman:

Chapter 7, Section 7.6, pp. 164-165, from section titled Microtubules up to subheader titled Motor Proteins Pull...

Becker:

Chapter 13, Section 13.2 through p. 361
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

 

 

 

 

 

Monday, April 16

Cytoskeleton IV – Centrosomes, Centrioles & Cilia

Freeman:

Chapter 7, Section 7.6, pp. 165-168, from section titled Motor Proteins Pull... to the end of the chapter

Becker:

Chapter 14, Section 14.1
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

Discussion 12: Vaccinations

 

 

 

Wednesday, April 18

Cell Cycle Introduction

 

Freeman:

Chapter 12, Sections 12.1 & 12.2

Becker:

Chapter 24, Section 24.1 & 24.2
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

 

 

 

 

 

 

 

Friday, April 20

The Events of M-Phase

 

Freeman:

Chapter 12, Sections 12.1 & 12.2 Becker:

Chapter 24, Section 24.1 & 24.2
For these readings from Becker, focus your primary attention on the big picture ideas, figures, tables, and bolded terms

 

 

 

 

 

Monday, April 23

 

Genetic Regulation in Bacteria I

Freeman:

Chapter 18, Sections 18.1 – 18.3
We will be working through an animated tutorial posted in Compass and you are encouraged to go through it before class

Discussion 13: Exam 4 (Final Exam) Preparation

 

 

 

 

Wednesday, April 25

Genetic Regulation in Bacteria  II,

Viruses I

Freeman:

Chapter 18, Sections 18.1 – 18.3 (Continued from Monday)

Chapter 33, pp. 682–687, up to section header "Analyzing the Phases of Replicative Growth"

 

 

 

Friday, April 27

 

Viruses II

Freeman:

Chapter 33, pp. 687-693, up to section 33.3

 

 

 

Monday, April 30

Recombinant DNA & Genetic Engineering I

Freeman:

Chapter 20, Section 20.1

No Discussions this week!

 

Wednesday, May 2

Recombinant DNA & Genetic Engineering II

Freeman:

Chapter 20, Section 20.

 

 

Thursday, May 3

 

Reading Day: No Classes

 

 

Thursday, May 10

 

Final Exam 8:00 – 11:00 AM