Recent Publications

View publications by Susan A. Martinis listed on the National Library of Medicine.

Zhao, H., Palencia, A., Seiradake, E., Ghaemi, Z., Cusask, S., Luthey-Schulten, Z., Martinis, S.A., (2015) Analysis of the Resistance Mechanism of a Benzoxaborole Inhibitor Reveals Insight into the Leucyl-tRNA Synthetase Editing Mechanism, ACS Chemical Biology,10(10):2277-85

Pang, Y.L., Poruri, K., Martinis, S.A., (2014) tRNA synthetase: tRNA aminoacylation and beyond, Wiley Interdiscip Rev RNA, 5(4):461-80

Yao, P., Poruri, K., Martinis, S.A., Fox, P.L., (2014) Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases, Top Curr Chem, 344:167-87

Li, L., Palencia, A., Lukk, T., Li, Z., Luthey-Schulten, Z.A., Cusack, S., Martinis, S.A., Boniecki, M.T., (2013) Leucyl-tRNA synthetase editing domain functions as a molecular rheostat to control condon ambiguity in Mycoplasma pathogens, Proc Natl Acad Sci U S A, 110(10):3817-22

Li, L., Martinis, S.A., Luthey-Schulten, Z., (2013) Capture and quality control mechanisms for adenosine-5'-triphosphate binding, J Am Chem Soc, 135(16):6047-55

Palencia, A., Crepin, T., Vu, M.T., Lincecum, T.L. Jr, Martinis, S.A., Cusack, S., (2012) Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase, Nat Struct Mol Biol, 19(7):677-84

Sarkar,J., Poruri, K., Boniecki, M.T., Mctavish, K.K., Martinis, S.A., (2012) Yeast mitochondrial leucyl-tRNA synthetase CP1 domain has functionally diverged to accommodate RNA splicing at expense of hydrolytic editing, J Biol Chem, 287(18):14772-81

Boniecki, M.T., Martinis, S.A., (2012) Coordination of tRNA synthetase active sites for chemical fidelity, J Biol Chem, 287(14):11285-9

Sarkar, J., Martinis, S.A., (2011) Amino-Acid-Dependent Shift in tRNA Synthetase Editing Mechanisms, J Am Chem Soc, 133(46):18510-13

Sarkar, J., Mao, W., Lincecum, T.L., Alley, M.R.K., Martinis, S.A., (2011) Characterization of Benzoxaborole-based Antifungal Resistance Mutations Demonstrates That Editing Depends on Electrostatic Stabilization of the Leucyl-tRNA Synthetase Editing Cap, FEBS Lett, 585 (2011):2986-91

Li Li, Boniecki, M.T., Jaffe, J.D., Imai, B.S., Yau, P.M., Luthey-Schulten, Z.A., Martinis, S.A., (2011) Naturally Occurring Aminoacyl-tRNA Synthetases Editing-Domain Mutations That Cause Mistranslation in Mycoplasma Parasites, Proc. Natl. Acad. Sci. U.S.A., 108(23):9378-83.

Boniecki, M.T., Martinis, S.A., (2010) The Balance Between Pre- and Post-transfer Editing in tRNA Synthetases, FEBS Lett, 584(2):455-9

Mascarenhas, A.P., Martinis, S.A., (2009) A Glycine Hinge for tRNA-Dependent Translocation of Editing Substrates to Prevent Errors by Leucyl-tRNA Synthetase, FEBS Lett, 583(21):3443-7

Pang, YL., Martinis, S.A., (2009) A Paradigm Shift for the Amino Acid Editing Mechanism of Human Cytoplasmic Leucyl-tRNA Synthetase, Biochemistry, 48(38):8958-64

Boniecki, M.T., Rho, SB., Tukalo, M., Hsu, J.L., Romero, E.P., Martinis, S.A., (2009) Leucyl-tRNA Synthetase -Dependent and -Independent Activation of a Group I Intron, J Biol Chem, 284(39):26243-50

Hellmann, R.A., Martinis, S.A., (2009) Defects in Transient tRNA Translocation Bypass tRNA Synthetase Quality Control Mechanisms, J Biol Chem, 284(17):11478-84.

Boniecki, M.T., Vu, M.T., Betha, A.K., Martinis, S.A. (2008) CP1-dependent Partitioning of Pretransfer and Posttransfer Editing in Leucyl-tRNA Synthetase, Proc. Natl. Acad. Sci. U.S.A., 105, 19223-19228

Mascarenhas, A.P., Martinis, S.A. (2008) Functional segregation of a predicted "hinge" site within the beta-strand linkers of Escherichia coli leucyl-tRNA synthetase, Biochemistry, 47(16):4808-16

Splan, K.E.*, Musier-Forsyth, K.**, Boniecki, M.T., Martinis, S.A. (2008) In vitro assays for the determination of aminoacyl-tRNA synthetase editing activity, Methods, 44(2):119-28
*Department of Chemistry, Macalester College, **Department of Chemistry, The Ohio State University

Karkhanis, V.A., Mascarenhas, A.P., Matinis, S.A. (2007) Amino Acid Toxicities of Escherichia Coli that are Prevented by Leucyl-tRNA Synthetase Amino Acid Editing, J. Bacteriol, 189(23):8765-8

Betha, A.K., Williams, A.M., Martinis, S.A. (2007) Isolated CP1 Domain of Escherichia Coli Leucyl-tRNA Synthetase is Dependent on Flanking Hinge Motifs for Amino Acid Editing Activity, Biochemistry, 46(21):6258-67

Vu, M.T., Martinis, S.A. (2007) A Unique Insert of a Leucyl-tRNA Synthetase is Required for Aminoacylation and Not Amino Acid Editing, Biochemistry, 46(17):5170-6

Zhai, Y., Nawaz, M.H., Lee, K.W., Kirkbride, E., Briggs, J.M., Martinis, S.A. (2007) Modulation of Substrate Specificity within the Amino Acid Editing Site of Leucyl-tRNA Synthetase, Biochemistry, 46(11):3331-7

Nawaz, M.H., Pang, Y.L., Martinis, S.A. (2007) Molecular and Functional Dissection of a Putative RNA-binding Region in Yeast MitochondrialLeucyl-tRNA Synthetase, J Mol Biol, 267(2):384-94

Karkhanis, V.A., Boniecki, M.T., Pururi, K., Martinis, S.A. (2006) A viable amino acid editing activity in the leucyl-tRNA synthetase CP1-splicing domain is not required in the yeast mitochondria, J Biol Chem, 281(44):33217-25.

Hsu, J.L., Rho, S.B., Vannella, K.M., Martinis, S.A. (2006) Functional divergence of a unique c-terminal domain of leucyl-tRNA synthetase to accommodate its splicing and aminoacylation roles, J Biol Chem,281(32):23075-8.

Williams, A.M. and Martinis, S.A. (2006) Mutational Unmasking of a tRNA-Dependent Pathway for Preventing Genetic Code Ambiguity, Proc. Natl. Acad. Sci. U.S.A., 103, 3586-35891.

Zhai, Y. and Martinis, S.A. (2005) Two Conserved Threonines Collaborate in the Escherichia coli Leucyl-tRNA Synthetase Amino Acid Editing Mechanism, Biochemistry, 44, 15437-15443.

Lincecum Jr., T.L.  and Martinis, S.A. (2004) Leucyl-tRNA Synthetases in  The Aminoacyl-tRNA Synthetases (Ibba, M., Francklyn, C., and Cusack, S., Eds.), pp. 36-46, Landes Bioscience.

Mursinna, R.S., Lee, K.W., Briggs, J.M., and Martinis, S.A. (2004) Molecular Dissection of a Critical Specificity Determinant within the Amino Acid Editing Domain of Leucyl-tRNA Synthetase, Biochemistry, 43, 155-165.

Lincecum* Jr.,T.L., Tukalo*, M., Yaremchuk*, A., Mursinna, R.S., Williams, A.M., Sproat, B.S., Van Den Eynde, W., Link, A., Calenbergh, S. V., Grotli, M., Martinis*, S.A., and Cusack*, S. (2003)  Structural and Mechanistic Basis of Pre- and Post-Transfer Editing by Leucyl-tRNA synthetase., Molecular Cell, 11, 951-963.

Rho, S.B., Lincecum Jr., T.L., and Martinis, S.A. (2002)  An Inserted Region of Leucyl-tRNA Synthetase Plays a Critical Role in Group I Intron Splicing. EMBO J., 21, 6874-6881.

Mursinna, R.S. and Martinis, S.A. (2002) Rational Design to Block Amino Acid Editing of a tRNA Synthetase.   J. Am. Chem. Soc., 124, 7286-7287.

Larkin, D.L., Williams, A.M., Martinis, S.A., and Fox, G.E.  (2002)  Identification of Essential Domains for Escherichia coli tRNALeu  Aminoacylation and Amino Acid Editing Using Minimalist RNA Molecules. Nucl. Acids Res., 30, 2097-2102.

Nagaswamy, U., Gao, X., Martinis, S.A., and Fox, G.E.  (2001) NMR Structure of a Ribosomal RNA Hairpin Containing a Conserved Pentaloop.  Nucl. Acids Res. 29, 5129-5139.

Larkin, D.,  Martinis, S.A., Roberts, D.J., and Fox, G.E.  (2001) Ala-His Mediated Peptide Bond Formation Revisited.   Orig. Life Evol.  Biosph, 31, 511-526.

Mursinna, R.S., Lincecum Jr., T.L., and Martinis, S.A. (2001)  A Conserved Threonine within Escherichia coli Leucyl-tRNA Synthetase Prevents Hydrolytic Editing  of  Leu-tRNALeu.  Biochemistry, 40,  5376-5381.

Rho, S.R. and Martinis, S.A. (2000) The bI4 Group I Intron Binds Directly to Both Its Protein Splicing Partners,  a tRNA Synthetase and Maturase, to Facilitate  RNA Splicing Activity. RNA 6, 1882-1894.

Houman, F., Rho, S.B.,  Zhang, J., Shen, X., Wang, C.-C., Schimmel, P., and Martinis, S.A. (2000)  A Prokaryotic and Human tRNA Synthetase Provide  an Essential RNA Splicing Function in Yeast Mitochondria. Proc. Natl. Acad. Sci., U.S.A.,  97, 13743-13748.

Martinis, S.A., Plateau, P., Cavarelli, J., and Florentz, C.  (1999)  Aminoacyl-tRNA Synthetases:  An Expanding Family of  Functions EMBO J., 18, 4591-4596.