Publications
(Click the thumbnails to enlarge)



34. Chorghade S*, Seimetz J*, Emmons, RS, Yang J, Bresson SM, De Lisio M, Parise, G, Conrad NK and Kalsotra A (2017) Poly(A) tail length regulates PABPC1 expression to tune translation in the heart. [pdf]
eLIFE doi:10.7554/eLife.24139.| * denotes equal authors

• Commentary by Gray and Gray [pdf]
• Highlighted by Nature Reviews Cardiology. [pdf]
• Chosen as the feature article for eLIFE.
• Press coverage [Link1] [Link2] [Link3] [Link4].






33. Lewis C, Pan T and Kalsotra A (2017) RNA modifications and structures cooperate to guide RNA-protein interactions.
Nature Reviews Mol. Cell Biol.(3):202-210. doi: 10.1038/nrm.2016.163. [pdf]





32. Aguero T, Jin Z, Chorghade S, Kalsotra A, King ML, Yang J (2017) Maternal dead-end 1 promotes translation of nanos1 through binding the eIF3 complex. Development. DOI: 10.1242/dev.152611. [pdf]





31. Liu DC, Seimetz J, Lee KY, Kalsotra A, Chung HJ, Lu H and Tsai NP (2017) Mdm2 mediates FMRP- and Gp1 mGluR-dependent protein translation and neural network activity. Hum. Mol. Genet. doi.org/10.1093/hmg/ddx276 [pdf]




30. Skariah G, Seimetz J, Norsworthy M, Lannom MC, Kenny PJ, Elrakhawy M, Forsthoefel C, Drnevich J, Kalsotra A, Ceman S (2017) Mov10 in developing brain suppresses retroelements and regulates neuronal development and function.
BMC Biol. 15:54. doi: 10.1186/s12915-017-0387-1 [pdf]





29. Yum K, Wang ET and Kalsotra A (2017) Myotonic dystrophy: disease repeat range, penetrance, age of onset, and relationship between repeat size and phenotypes.
Curr. Opin. Genet. Dev. 44:30-37. doi: 10.1016/j.gde.2017.01.007. [pdf]





28. Arif W, Datar G and Kalsotra A (2017) Intersections of post-transcriptional gene regulatory mechanisms with intermediary metabolism.
Biochim. Biophys. Acta. 1860(3):349-362. doi: 10.1016/j.bbagrm.2017.01.004. [pdf]





27. Bangru S and Kalsotra A (2016) Advances in analyzing RNA diversity in eukaryotic transcriptomes: peering through the Omics lens.
F1000Research. 5:2668 doi: 10.12688/f1000research.9511.1 [pdf]




26. Bhate A*, Parker DJ*, Bebee TW, Ahn J, Arif W, Rashan EH, Chorghade S, Chau A, Lee JH, Anakk S, Carstens RP, Xiao X and Kalsotra A (2015) ESRP2 controls an adult splicing program in hepatocytes to support postnatal liver maturation.
Nature Commun. 6:8768 | DOI: 10.1038/ncomms9768 [pdf]
| * denotes equal authors

• Press coverage [Link1] [Link2] [Link3].




25. Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH and Bellen HJ. (2015) Impaired Mitochondrial Energy Production Causes Light-Induced Photoreceptor Degeneration Independent of Oxidative Stress.
PLoS Biol. 13(7): e1002197. doi:10.1371/journal.pbio.1002197 [pdf]

• Chosen as the cover article for PLoS Biol.





24. Li W, You B, Hoque M, Luo W, Park JY, Ji Z, Zheng D, Gunderson SI, Kalsotra A, Manley JL and Tian B (2015). Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation.
PLoS Genet. doi:10.1371/journal.pgen.1005166 [pdf]





23. Chaturvedi P, Neelamraju Y, Arif W, Kalsotra A , and Janga SC (2015). Uncovering RNA binding proteins associated with age and gender during liver maturation.
Sci. Rep. 5: 9512 doi:10.1038/srep09512 [pdf]





22. Chau AC and Kalsotra A. (2015). Developmental insights into the pathology and therapeutic strategies for DM1: Back to the basics.
Dev. Dyn. 244:377–390.doi: 10.1002/DVDY.24240 [pdf]




21. Singh RK, Xia Z, Bland CS, Kalsotra A, Ruddy M, Curk T, Ule J, Li W and Cooper, TA (2014). Rbfox2-coordinated alternative splicing of Mef2d and Rock2 controls myoblast fusion during myogenesis.
Mol. Cell. 55(4):592-603 doi: 10.1016/j.molcel.2014.06.035 [Link to Journal]

• Press coverage [Link1] [Link2].




20. Giudice J, Xia Z, Wang ET, Scavuzzo MA, Ward AJ, Kalsotra A, Wang W, Wehrens XH, Burge CB, Li W, Cooper TA.(2014). Alternative splicing regulates vesicular trafficking genes in cardiomyocytes during postnatal heart development.
Nature Commun. 5:3603. doi: 10.1038/ncomms4603 [pdf]

• Press coverage [Link1] [Link2].




19. Kalsotra A, Singh RK, Gurha P, Ward AJ, Creighton CJ, Cooper TA.(2014). The Mef2 Transcription Network Is Disrupted in Myotonic Dystrophy Heart Tissue, Dramatically Altering miRNA and mRNA Expression.
Cell Rep. 6(2):336-45. doi: 10.1016/j.celrep.2013. 12.025. [pdf]

• Press coverage [Link1] [Link2] [Link3]




18. Kalsotra A and Cooper TA (2011). Functional consequences of developmentally regulated alternative splicing.
Nat. Rev. Genet. 12: 715-29 [pdf]

• Chosen as the featured article and cover illustration for Nat. Rev. Genet.



17. Kalsotra A, Wang K, Li PF, and Cooper TA (2010). MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development.
Genes Dev. 24: 653-58 [pdf]

• Chosen as the cover article for Genes Dev.
• Recommended by Faculty of 1000.




16. Kalsotra A, Xiao X, Ward A, Castle JC, Johnson JM, Burge CB, and Cooper TA (2008). A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.
Proc. Natl. Acad. Sci. USA. 105(51):20333-8. [pdf]

• Reported as “Research News” by Physorg.com, From the Labs at BCM, Redorbit.com, Sciencetoday.com and Medical News Today.





15. Castle JC, Zhang C, Shah JK, Kulkarni AV, Kalsotra A, Cooper TA and Johnson JM (2008) Differential expression of 24,426 human alternative splicing events and predicted cis-regulation in 48 tissues and cell lines.
Nat. Genet. 40(12):1416-25. [pdf]

• Multitudes of Messages. Editorial in Nat. Genet. 40, 1385




14. Kalsotra A, Du L, Wang Y, Ladd PA, Kikuta Y, Duvic M, Boyd AS, Keeney DS, and Strobel HW (2008). Inflammation resolved by retinoid X receptor-mediated inactivation of leukotriene signaling pathways.
FASEB J. 22(2):538-47. [pdf]

13. Wang Y, Zhao J, Kalsotra A, Turman CM, Grill RJ, Dash PK, Strobel HW (2008). CYP4Fs expression in rat brain correlates with changes in LTB(4) levels after traumatic brain injury.
J. Neurotrauma. 25(10):1187-94. [pdf]

• Chosen as the cover article for J. Neurotrauma.




12. Kalsotra A, Anakk S, Brommer CL, Kikuta Y, Morgan ET, and Strobel HW. (2007). Catalytic characterization and cytokine mediated regulation of Cytochrome P450 4Fs in rat hepatocytes.
Arch. Biochem. Biophys. 461(1): 104-112. [pdf]


11. Kalsotra A, Zhao J, Anakk S, Dash PK, and Strobel HW. (2007). Brain trauma leads to enhanced lung inflammation and injury: evidence for role of P4504Fs in resolution.
J. Cereb. Blood Flow Metab. 27(5): 963-974. [pdf]

• Recommended by Faculty of 1000.

10. Kalsotra A, and Strobel HW (2006). Cytochrome P450 4F subfamily: at the crossroads of eicosanoid and drug metabolism.
Pharmacol. Ther. 112(3): 589-611. [pdf]

9. Kalsotra A, Cui X, Anakk S, Hinojos CA, Doris PA, and Strobel HW. (2005). Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats.
Biochem. Biophys. Res. Commun. 338(1): 423-431. [pdf]


8. Kalsotra A, Turman CM, Kikuta Y and Strobel HW (2004). Expression and characterization of human Cytochrome P450 4F11. Putative role in the metabolism of therapeutic drugs and eicosanoids.
Toxicol. Appl. Pharmacol. 199(3):295-304. [pdf]


7. Anakk S, Kalsotra A, Kikuta Y, Huang W, Zhang J, Staudinger JL, Moore DD, and Strobel HW (2004). CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11.
Pharmacogenomics J. 4: 91-101 [pdf]


6. Kalsotra A, Turman CM, Dash PK and Strobel HW (2003). Differential effects of Traumatic Brain Injury on the Cytochrome P450 System: A perspective into hepatic and renal drug metabolism.
J. Neurotrauma. 20(12): 1339-50. [pdf]


5. Kalsotra A, Cui X, Antonovic L, Robida AM, Morgan ET and Strobel HW (2003). Inflammatory prompts produce isoform specific changes in the expression of leukotriene B4 ω- hydroxylases in rat liver and kidney.
FEBS Lett. 555(2): 236-42. [pdf]


4. Anakk S, Kalsotra A, Shen Qi, Vu MT, Staudinger JL, Davies P.J and Strobel HW (2003). Genomic characterization and regulation of CYP3a13: Role of xenobiotics and nuclear receptors.
FASEB J. 17(12):1736-8. [pdf]


3. Cui X, Kalsotra A, Robida AM, Matzilvich D, Moore AN, Boehme CL, Morgan ET, Dash PK and Strobel HW (2003). Expression of cytochromes 4F4 and 4F5 in infection and injury models of inflammation.
Biochim. Biophys. Acta. 1619, 325-31. [pdf]


2. Kalsotra A, Anakk S, Boehme CL and Strobel HW (2002). Sexual dimorphism and tissue specificity in the expression of CYP 4F forms in Sprague Dawley rats.
Drug Metab. Dispos. 30, 1022-28. [pdf]


1. Palit G, Kalsotra A, Kumar R, Nath C and Dubey MP (2001). Behavioral and anti-psychotic effects of Ca2+ channel blockers in rhesus monkey.
Eur. J. Pharmacol. 412(2), 139-44. [pdf]



Book Chapters

3. Kalsotra A (2015). Erythromycin mechanism (antibiotic); case #9 in Casefiles: Biochemistry. E Toy, W Seifert Jr., HW Strobel and K Harms (eds), LANGE SERIES by Mcgraw-Hill UK, pps. 83-91


2. Kalsotra A (2015). Quinolone use (pelvic inflammatory disease); case #10 in Casefiles: Biochemistry. E Toy, W Seifert Jr., HW Strobel and K Harms (eds), LANGE SERIES by Mcgraw- Hill UK, pps. 93-101


1. Strobel HW, Kalsotra A, and Dash PK (2003). Cytochrome P450 4Fs: Response and role following brain trauma, in Cytochrome P450, Biochemistry Biophysics & Drug Metabolism. P Anzenbacher and J Hudecek (eds), MONDUZZI EDITORE: Prague, pps. 107-114