Dr. Chaitali Misra

Postdoctoral Research Associate


Ph.D. - Indian Institute of Chemical Biology

Started in Lab: December 2014


Email: chaitali.misra@gmail.com


Funding: Post-doc fellowship from American Heart Association (2016-2018)

Publications



Chaitali Misra*, Sheng-Wei Chang*, Madhumita Basu, Nianyuan Huang and Vidu Garg. ‘Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation’. Human Molecular Genetics, 2014 Oct; 23(19):5025-35. doi: 10.1093/hmg/ddu215.

Chaitali Misra and Vidu Garg. ‘Compacting the heart with Notch’. Nature Medicine (News & Views) 2013 February 6 (19) 133-134 doi:10.1038/nm.3071 (PMID: 23389606).

Chaitali Misra, Nita Sachan, Caryn Rothrock McNally, Sara N. Koenig, Caryn Rothrock McNally, Haley A. Nichols, Anuradha Guggilam, Pamela A. Lucchesi, William T. Pu, Deepak Srivastava and Vidu Garg. ‘Human CHD Causing Mutation GATA4 G296S Mutation Displays Cardiomyocyte Proliferation Deficits in vivo’. PLoS Genetics 2012 May; 8(5): e1002690. Epub 2012 May 10 (PMID: 22589735).

Chaitali Misra, Mousumi Majumder, Swati Bajaj, Saurabh Ghosh, Bidyut Roy and Susanta Roychoudhury. ‘Polymorphisms at p53, p73 and MDM2 loci Modulate the risk of Tobacco Associated Leukoplakia and Oral Cancer’. Molecular Carcinogenesis 2009 Sep; 48(9): 790-800 (PMID: 19204927).



Biography







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I am a Research Associate in the Kalsotra lab. I did my PhD from the Indian Institute of Chemical Biology, Kolkata, India on Cancer Genetics. My domain got diversified to genetics of cardiac development when I joined Nationwide Children's Hospital, Ohio as a postdoctoral fellow. I love movies and music but most of all I love to spend time with my family.

I have previously studied the role of a Gata4 point mutation found in a human family with congenital heart disease using knock in mutant mouse model, which identified a defect in cardiomyocyte cell proliferation during heart development. I also described interactions between Gata4 and Tbx5, which when disrupted lead to defects in cardiomyocyte proliferation and atrioventricular septal defects.

In the Kalsotra lab, I am focusing on studying the function of Rbfox2, a highly conserved RNA binding protein, in alternative splicing regulation during mouse heart development. During early embryonic stages the heart grows through rapid proliferation of cardiomyocytes, however the postnatal growth occurs primarily via hypertrophic rather than hyperplastic pathways. Large-scale splicing transitions are known to occur during late embryonic and early postnatal stages of heart development, which are misregulated in heart disease. I am using cardiac-specific knockout and transgenic mice coupled with next-generation sequencing methods to study the role of Rbfox2-splicing network under physiologic and pathologic conditions of the heart.