Dr. Bo Zhang

Postdoctoral Research Associate


Ph.D. - The Ohio State University

Started in the Lab: September 2017


Email: zhang372@illinois.edu


Publications

Zhang B, Shi Q, Varia SN, Xing S, Klett BM, Cook LA and Herman PK (2016) The activity-dependent regulation of protein kinase stability by the localization to P-bodies. Genetics. 203(3): 1191-202.

Nostramo R, Varia SN, Zhang B, Emerson MM, Herman PK (2015) The catalytic activity of the Ubp3 deubiquitinating protease is required for efficient stress granule assembly in S. cerevisiae. Mol Cell Biol. 36(1): 173-83.

Shah KH, Nostramo R, Zhang B, Varia SN, Klett BM and Herman PK (2014) Protein kinases are associated with multiple, distinct cytoplasmic granules in quiescent yeast cells. Genetics. 198(2): 1495-1512.

Shah KH, Zhang B, Ramachandran V, Herman PK. Processing body and stress granule assembly occur by independent and differentially regulated pathways in Saccharomyces cerevisiae. Genetics. 193(1):109-23.


Biography

Hi, I am Bo Zhang, a postdoctoral fellow in the Kalsotra laboratory. I got my Ph.D. in Molecular Genetics from The Ohio State University. During my graduate career, I studied the regulation and function of P-bodies, a type of RNA-protein (RNP) granule that has been conserved through evolution.


Research

In the laboratory, I am interested in investigating the function and regulation of poly(A) binding proteins (PABPs) during heart development and disease. PABPs are multifunctional scaffolds that bind to the poly(A) tail to form ribonucleoproteins and determine the post-transcriptional fate of an mRNA including its export, stability, and translation. Recently the Kalsotra group discovered that PABPs are post-transcriptionally silenced in the adult human and mouse hearts. The silencing is cardiomyocyte-specific, evolutionarily conserved, and reversed during heart disease.

I am particularly interested in determining -

• Why are PABP mRNAs not translated in the adult mammalian heart?
• What is the requirement of PABPs in cardiac growth and hypertrophy?
• What is their general role in modulating poly(A) tail length and translation in heart?

I will be using next-generation sequencing, mass spectrometry and polysome profiling techniques on cultured cells and transgenic mouse models to answer these questions.