• Global analyses of mRNA splicing and translation to identify conserved gene regulatory programs.

• Cell- and tissue-specific gene targeting in mice to define in vivo function(s) of RNA binding proteins.

• Use of microRNAs, anti-sense oligonucleotides and small molecules as RNA therapeutics.

Welcome to the Kalsotra Laboratory!

The research in Kalsotra laboratory brings together critical ideas in the fields of molecular and developmental biology and offers a robust framework to better understand how, when, and where particular mRNAs are translated into proteins.

We are particularly interested in understanding (i) how post-transcriptional regulatory mechanisms integrate with transcriptional and translational programs to ensure normal tissue development and function, (ii) why misregulation of such mechanisms results in disease, and (iii) whether these mechanisms can be leveraged to prevent or reverse specific cardiac and liver disorders.

We strive to provide a training environment that encourages independent thinking and creativity.


Lab Location-
University of Illinois
462 Medical Science Building
506 South Mathews Ave.
Urbana, IL 61801

Telephone: 217-300-5531
Fax: 217-244-5858
Email: kalsotra at uiuc dot edu

Latest News
July 2017- Sandip and Joe's paper published in eLIFE as "Cover Story". [Link1] [Link2] [Link3]

Mar 2017- Cole's review published in Nature Reviews Molecular Cell Biology. [Link]

Feb 2017- Kevin's review published in Current Opinion in Genetics and Development. [Link]

Nov 2015- Amruta's paper published in Nature Commun. [Link1] [Link2] [Link3]
Jan 2018- Joe receives 2yr AHA Fellowship.

Aug 2017- MDA funds the Kalsotra Lab. [Link]

July 2016- Chaitali receives 2yr AHA Fellowship.

May 2016- Waqar receives 5yr NRSA Fellowship.

Jan 2016- Nash is selected as CAS Fellow. [Link]
Research Presentations
August 2017- Chaitali's abstract selected for a talk at IDMC-11 meeting in San Francisco, CA. [Link]

June 2017- Nash gave an oral presentation at the "19th ISCHS meeting" in Galway, Ireland. [Link]