Publications from 2008

Changes to NIH grant system may backfire.
Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE.
Science. 2008 Nov 21;322(5905):1187-8. No abstract available. Pubmed

Discovery of a dipeptide epimerase enzymatic function guided by homology modeling and virtual screening.
Kalyanaraman C, Imker HJ, Fedorov AA, Fedorov EV, Glasner ME, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP.
Structure. 2008 Nov 12;16(11):1668-77. Pubmed

Mechanistic diversity in the RuBisCO superfamily: a novel isomerization reaction catalyzed by the RuBisCO-like protein from Rhodospirillum rubrum.
Imker HJ, Singh J, Warlick BP, Tabita FR, Gerlt JA.
Biochemistry. 2008 Oct 28;47(43):11171-3. Epub 2008 Oct 1. Pubmed

Evolution of enzymatic activities in the enolase superfamily: L-rhamnonate dehydratase.
Rakus JF, Fedorov AA, Fedorov EV, Glasner ME, Hubbard BK, Delli JD, Babbitt PC, Almo SC, Gerlt JA.
Biochemistry. 2008 Sep 23;47(38):9944-54. Epub 2008 Aug 29. Pubmed

Crystal structure and functional assignment of YfaU, a metal ion dependent class II aldolase from Escherichia coli K12.
Rea D, Hovington R, Rakus JF, Gerlt JA, Fulop V, Bugg TD, Roper DI.
Biochemistry. 2008 Sep 23;47(38):9955-65. Epub 2008 Aug 29. Pubmed

Structural basis for substrate specificity in phosphate binding (beta/alpha)8-barrels: D-allulose 6-phosphate 3-epimerase from Escherichia coli K-12.
Chan KK, Fedorov AA, Fedorov EV, Almo SC, Gerlt JA.
Biochemistry. 2008 Sep 9;47(36):9608-17. Epub 2008 Aug 14. Pubmed

Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach.
Barnett SA, Amyes TL, Wood BM, Gerlt JA, Richard JP.
Biochemistry. 2008 Jul 29;47(30):7785-7. Epub 2008 Jul 4. Pubmed

Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP.
Amyes TL, Wood BM, Chan K, Gerlt JA, Richard JP.
J Am Chem Soc. 2008 Feb 6;130(5):1574-5. Epub 2008 Jan 11. No abstract available. Pubmed