Publications from 2003

How to find "missing" genes.
Gerlt JA.
Chem Biol. 2003 Dec;10(12):1141-2. Pubmed

Evolution of enzymatic activity in the enolase superfamily: structural and mutagenic studies of the mechanism of the reaction catalyzed by o-succinylbenzoate synthase from Escherichia coli.
Klenchin VA, Taylor Ringia EA, Gerlt JA, Rayment I.
Biochemistry. 2003 Dec 16;42(49):14427-33. Pubmed

Chemical and enzymatic synthesis of fluorinated-dehydroalanine-containing peptides.
Zhou H, Schmidt DM, Gerlt JA, van der Donk WA.
Chembiochem. 2003 Nov 7;4(11):1206-15. Pubmed

Structural evidence for a 1,2-enediolate intermediate in the reaction catalyzed by 3-keto-L-gulonate 6-phosphate decarboxylase, a member of the orotidine 5'-monophosphate decarboxylase suprafamily.
Wise EL, Yew WS, Gerlt JA, Rayment I.
Biochemistry. 2003 Oct 28;42(42):12133-42. Pubmed

Divergent function in the crotonase superfamily: an anhydride intermediate in the reaction catalyzed by 3-hydroxyisobutyryl-CoA hydrolase.
Wong BJ, Gerlt JA.
J Am Chem Soc. 2003 Oct 8;125(40):12076-7. Erratum in: J Am Chem Soc. 2004 Feb 18;126(6):1921. Pubmed

Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily.
Schmidt DM, Mundorff EC, Dojka M, Bermudez E, Ness JE, Govindarajan S, Babbitt PC, Minshull J, Gerlt JA.
Biochemistry. 2003 Jul 22;42(28):8387-93. Pubmed

Evolutionary potential of (beta/alpha)8-barrels: functional promiscuity produced by single substitutions in the enolase superfamily.
Schmidt DM, Mundorff EC, Dojka M, Bermudez E, Ness JE, Govindarajan S, Babbitt PC, Minshull J, Gerlt JA.
Biochemistry. 2003 Jul 22;42(28):8387-93. Pubmed

Identification and characterization of a mandelamide hydrolase and an NAD(P)+-dependent benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633.
McLeish MJ, Kneen MM, Gopalakrishna KN, Koo CW, Babbitt PC, Gerlt JA, Kenyon GL.
J Bacteriol. 2003 Apr;185(8):2451-6. Pubmed