Publications from 2000

Can sequence determine function?
Gerlt JA, Babbitt PC.
Genome Biol. 2000;1(5):REVIEWS0005. Epub 2000 Nov 8. Review. Pubmed

New functions from old scaffolds: how nature reengineers enzymes for new functions.
Babbitt PC, Gerlt JA.
Adv Protein Chem. 2000;55:1-28. Review. No abstract available. Pubmed

Mechanisms. Mechanisms Of catalysis - macroscopic and microscopic progress
Marletta MA, Gerlt JA.
Curr Opin Chem Biol. 2000 Oct;4(5):531-2. No abstract available. Pubmed

Evolution of enzymatic activity in the enolase superfamily: structure of o-succinylbenzoate synthase from Escherichia coli in complex with Mg2+ and o-succinylbenzoate.
Thompson TB, Garrett JB, Taylor EA, Meganathan R, Gerlt JA, Rayment I.
Biochemistry. 2000 Sep 5;39(35):10662-76. Pubmed

New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli.
Benning MM, Haller T, Gerlt JA, Holden HM.
Biochemistry. 2000 Apr 25;39(16):4630-9. Pubmed

Discovering new enzymes and metabolic pathways: conversion of succinate to propionate by Escherichia coli.
Haller T, Buckel T, Rétey J, Gerlt JA.
Biochemistry. 2000 Apr 25;39(16):4622-9. Pubmed

Evolution of enzymatic activities in the enolase superfamily: crystallographic and mutagenesis studies of the reaction catalyzed by D-glucarate dehydratase from Escherichia coli.
Gulick AM, Hubbard BK, Gerlt JA, Rayment I.
Biochemistry. 2000 Apr 25;39(16):4590-602. Pubmed

New wine from old barrels.
Gerlt JA.
Nat Struct Biol. 2000 Mar;7(3):171-3. No abstract available. Pubmed