Publications from 2012

Proton Transfer from C-6 of Uridine 5'-Monophosphate Catalyzed by Orotidine 5'-Monophosphate Decarboxylase: Formation and Stability of a Vinyl Carbanion Intermediate and the Effect of a 5-Fluoro Substituent.
Tsang WY, Wood BM, Wong FM, Wu W, Gerlt JA, Amyes TL, Richard JP.
J Am Chem Soc. 2012 Aug 21. Pubmed

Orotidine 5'-monophosphate decarboxylase: transition state stabilization from remote protein-phosphodianion interactions.
Amyes TL, Ming SA, Goldman LM, Wood BM, Desai BJ, Gerlt JA, Richard JP.
Biochemistry. 2012 Jun 12;51(23):4630-2. Epub 2012 May 31. Pubmed

Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.
Lukk T, Sakai A, Kalyanaraman C, Brown SD, Imker HJ, Song L, Fedorov AA, Fedorov EV, Toro R, Hillerich B, Seidel R, Patskovsky Y, Vetting MW, Nair SK, Babbitt PC, Almo SC, Gerlt JA, Jacobson MP.
Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4122-7. Epub 2012 Mar 5. Pubmed

Divergent evolution in enolase superfamily: strategies for assigning functions.
Gerlt JA, Babbitt PC, Jacobson MP, Almo SC.
J Biol Chem. 2012 Jan 2;287(1):29-34. Epub 2011 Nov 8. Review. Pubmed